Dr C Venkateshappa

Professor, Biochemistry

Dr C Venkateshappa is a distinguished Professor Grade I in Biochemistry, boasting over 30 years of experience in teaching and pioneering research. His career is marked by a profound dedication to advancing biochemical understanding and fostering the next generation of medical professionals.

His academic journey has seen him impart in-depth knowledge of biochemistry, molecular biology, and clinical chemistry at various prestigious medical colleges.

His professional experience spans several renowned institutions, including Sri Siddhartha Medical College, NIMHANS, and Saptagiri Medical Institute of Medical Sciences and Research Centre, culminating in his current role at Sri Madhusudan Sai Institute of Medical Sciences and Research.

His teaching philosophy emphasizes critical thinking and the practical application of biochemistry in medicine, earning him the respect of students and colleagues alike. He has been a mentor to countless students, guiding them through complex biochemical concepts and nurturing a passion for research.

Dr Venkateshappa’s research profile is equally impressive, with over 20 publications in peer-reviewed journals and more than 1,000 citations. His work focuses on the molecular mechanisms of diseases, particularly neurodegenerative disorders and fatty liver disease, and the role of enzymes and proteins in human health. His research has significantly contributed to bridging the gap between education and practice in the medical field.

His research has explored various aspects of oxidative stress, antioxidant function, and mitochondrial function in neurodegenerative diseases, contributing valuable insights into the biochemical pathways involved.

His core values are rooted in compassion for teaching and research, reflecting his lifelong commitment to advancing the field of biochemistry. At SMSIMSR, he values the core values, culture, and infrastructure, finding the compassionate care provided particularly meaningful. His approach to patient care centres on diagnostic services at the Clinical Biochemistry Lab.

Specialisations

  • Clinical Biochemistry
  • Neurochemistry

Areas of Interest

  • Molecular Diagnostics
  • Fatty Liver diseases
  • Neurodegenerative diseases

Academic Qualifications

  • M.Sc
  • Ph.D – Biochemistry

Professional Affiliations or Accreditations

NA

Research Publications

  • Venkateshappa C, Harish G, Mahadevan A, Bharath MMS. Elevated oxidative stress and decreased antioxidant function in the human hippocampus and frontal cortex with increasing age: implications for neurodegeneration in Alzheimer’s disease. Neurochem Res. 2012;37:1601–1614.
  • Venkateshappa C, Harish G, Mythri RB, Mahadevan A, Bharath MMS. Increased oxidative damage and decreased antioxidant function in aging human substantia nigra compared to striatum: implications for Parkinson’s disease. Neurochem Res. 2012;37:358–369.
  • Mythri RB, Venkateshappa C, Harish G, Mahadevan A, Muthane UB, Bharath MMS. Evaluation of markers of oxidative stress, antioxidant function and astrocytic proliferation in the striatum and frontal cortex of Parkinson’s disease brains. Neurochem Res. 2011;36:1452–1463.
  • Harish G, Venkateshappa C, Mythri RB, Dubey SK, Mishra K, Singh N, et al. Bioconjugates of curcumin display improved protection against glutathione depletion mediated oxidative stress in a dopaminergic neuronal cell line: implications for Parkinson’s disease. Bioorg Med Chem. 2010;18(7):2631–2638.
  • Harish G, Venkateshappa C, Mahadevan A, Pruthi N, Bharath MMS. Mitochondrial function in human brains is affected by pre‐ and post mortem factors. Neuropathol Appl Neurobiol. 2013;39(3):298–315.
  • Harish G, Venkateshappa C, Mahadevan A, Pruthi N, Bharath MMS. Glutathione metabolism is modulated by postmortem interval, gender difference and agonal state in postmortem human brains. Neurochem Int. 2011;59(7):1029–1042.
  • Malviya M, Kumar YCS, Mythri RB, Venkateshappa C, Subhash MN, Bharath MMS. Muscarinic receptor 1 agonist activity of novel N-aryl carboxamide substituted 3-morpholino arecoline derivatives in Alzheimer’s presenile dementia models. Bioorg Med Chem. 2009;17(15):5526–5534.
  • Harish G, Venkateshappa C, Mahadevan A, Pruthi N, Bharath MMS. Effect of storage time, postmortem interval, agonal state, and gender on the postmortem preservation of glial fibrillary acidic protein and oxidatively damaged proteins in human brain. Biopreserv Biobank. 2011;9(4):379–387.
  • Harish G, Venkateshappa C, Mahadevan A, Pruthi N, Bharath MMS. Effect of premortem and postmortem factors on the distribution and preservation of antioxidant activities in the cytosol and synaptosomes of human brains. Biopreserv Biobank. 2012;10(3):253–265.
  • Mani PM, Swamy RM, Manjunath GN, Venkatesh G, Venkateshappa C, et al. Attitude of dental students towards their oral health care. Res J Pharm Biol Chem Sci. 2013;4(1):755.
  • Rangareddy H, Chikkanarayanappa V, Hayfa R, Srinivasaiah A, Venkateshappa C, et al. Leptin and aging: intriguing link to gut microbiota. Aging Pathobiol Ther. 2024;6(1).
  • Venkatapathappa C, Sultana A, Vidhya KS, Mansour R, Venkateshappa C, et al. Ocular pathology and genetics: transformative role of artificial intelligence (AI) in anterior segment diseases. Cureus. 2024;16(2).
  • Misquith A, Rangareddy H, Chikkanarayanappa V, Sultana A, Venkateshappa C, et al. Mathematical model for assessing glycemic control in type 2 diabetes mellitus. Bioinformation. 2024;20(2):116.
  • Venkateshappa C, Rangareddy H. Serum uric acid levels in type 2 diabetes mellitus among South Indian urban population: A cross-sectional study. J Biomed Pharm Res. 2020;9(6):20–24.
  • Ashakiran S, Ravish H, Venkateshappa C. Evaluation of novel biochemical markers in Sudarshan Kriya Yoga (SKY) practicing individuals. RGUHS Natl J Public Health. 2018;3(2).
  • Navyashree KM, Venkateshappa C. Role of serum oxidants and antioxidants as biomarkers in maturity onset diabetes of the young (MODY). J Clin Biomed Sci. 2016;6(3):84–87.
  • Venkateshappa C, Gangadharappa H. Pathophysiology of brain aging: A brief account on molecular changes. J Clin Biomed Sci. 2015;5(2):54–63.
  • Ravish H, Venkateshappa C. Evaluation of fibrinogen, total antioxidant capacity and body mass index in essential hypertensive men. Res J Pharm Biol Chem Sci. 2014;5(6):1082.
  • Babu MR, Gangadharappa H, Venkateshappa C, Bharath S. Evaluation of oxidative/nitrosative stress markers in non-SN regions of post-mortem Parkinson’s disease brain: Neuroprotection by natural antioxidant. Mov Disord. 2012;27(Suppl 1):S38.

Languages Spoken

English, Kannada, Telugu